ITGA8

Across TCGA cell cohorts, ITGA8 RNA expression is significantly associated with the go_rna of many other GO terms, with 809 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ITGA8-associated GO terms across cancer lineages are Negative regulation of bicellular tight junction assembly, Schwann cell differentiation, and Maintenance of postsynaptic density structure. Each is linked with ITGA8 in more than 4 cancer types. Because this analysis shows association rather than direction, both ITGA8-to-partner and partner-to-ITGA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of bicellular tight junction assembly grouped by ITGA8-low versus ITGA8-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA8→partner) and Y-score (partner→ITGA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of bicellular tight junction assembly →	+0.203	+1.472	<.001	.005	3	5
SKIN	Schwann cell differentiation →	+0.082	+0.413	<.001	.006	3	4
BONE	Maintenance of postsynaptic density structure →	-0.163	-0.992	<.001	.009	3	4
BONE	Amyloid-beta clearance by transcytosis →	+0.150	+1.000	<.001	.009	2	5
BONE	Myelination in peripheral nervous system →	+0.096	+0.998	.001	.009	2	5
BONE	Peripheral nervous system axon ensheathment →	+0.096	+0.998	.001	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 809 associations by consensus.

Negative regulation of bicellular tight junction assembly by ITGA8 expression — BONE

Explore this box plot interactively →