ITGA8

Across TCGA cell cohorts, ITGA8 mutation is significantly associated with the RNA expression of many other genes, with 244 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ITGA8-associated genes across cancer lineages are CLRN2, OR8B12, and ZNF729. Each is linked with ITGA8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGA8-to-partner and partner-to-ITGA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLRN2 grouped by ITGA8-low versus ITGA8-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA8→partner) and Y-score (partner→ITGA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLRN2 →	+0.021	+2.434	.002	.005	3	3
BLOOD_Lymphoma	OR8B12 →	+0.060	+3.925	<.001	.006	3	2
BLOOD_Lymphoma	ZNF729 →	+0.322	+3.794	<.001	.001	3	2
BLOOD_Lymphoma	USP17L4 →	+0.007	+3.794	<.001	.001	3	2
LUNG_NSCLC_LUAD	DNAH6 →	+0.297	+3.694	.005	<.001	3	2
OESOPHAGUS	TAS2R39 →	+0.043	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 244 associations by consensus.

CLRN2 by ITGA8 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →