ITGA6

Across TCGA pan-cancer cohorts, ITGA6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ITGA6 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ITGA6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ITGA6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, LUAD, and OV are the cancer types where ITGA6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.838	0.546	.017	27	view →
LUAD	DFS	Quartile	All	0.857	0.996	.006	26	view →
OV	DFS	Median	All	0.561	0.938	.006	24	view →
GBM	DFS	Quartile	All	0.302	0.521	.015	14	view →
PDAC	DFS	Quartile	All	0.767	0.977	.013	7	view →
LSCC	OS	Quartile	II,III,IV	0.522	0.865	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ITGA6–CCRCC (OS)

Open the CCRCC breakdown →