ITGA6

Across TCGA patient cohorts, ITGA6 mutation is significantly associated with the RNA expression of many other genes, with 4,116 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGA6-associated genes across cancer lineages are MIR4497, LDHA, and POLR3D. Each is linked with ITGA6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGA6-to-partner and partner-to-ITGA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4497 grouped by ITGA6-low versus ITGA6-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA6→partner) and Y-score (partner→ITGA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR4497 →	+0.329	+3.320	<.001	.008	3	3
UCEC	LDHA →	+0.418	+1.447	.004	.003	3	3
UCEC	POLR3D →	+0.400	+1.777	<.001	.002	3	3
UCEC	EXOSC10 →	+0.302	+1.872	.003	<.001	3	3
UCEC	CDC7 →	+0.688	+1.946	<.001	<.001	3	3
UCEC	HMCES →	+0.304	+1.664	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,116 associations by consensus.

MIR4497 by ITGA6 expression — BLCA

Explore this box plot interactively →