ITGA6

Across TCGA patient cohorts, ITGA6 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGA6-associated genes across cancer lineages are Shc_pY317, Caspase-7-cleavedD198, and eEF2. Each is linked with ITGA6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGA6-to-partner and partner-to-ITGA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by ITGA6-low versus ITGA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA6→partner) and Y-score (partner→ITGA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.194	-1.999	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.698	+1.534	<.001	.008	3	3
UCEC	eEF2 →	+0.265	+1.906	.014	.014	3	2
UCEC	FoxM1 →	+0.219	+1.321	.005	.012	3	2
UCEC	Notch1 →	+0.188	+2.273	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.432	-1.736	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Shc_pY317 by ITGA6 expression — UCEC

Explore this box plot interactively →