ITGA6-AS1

Across TCGA pan-cancer cohorts, ITGA6-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ITGA6-AS1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher ITGA6-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGA6-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

MESO, SKCM, and HNSC are the cancer types where ITGA6-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	III,IV	0.266	0.514	<.001	70	view →
SKCM	OS	Median	All	0.428	0.256	<.001	54	view →
HNSC	DFS	Quartile	II,III,IV	0.404	0.254	.007	48	view →
KIRP	DFS	Median	IV	0.040	0.622	.006	47	view →
LGG	DFS	Tertile	All	0.272	0.490	<.001	45	view →
UCS	OS	Quartile	II,III,IV	0.191	0.618	.020	36	view →
GBM	OS	Median	All	0.341	0.481	.003	30	view →
UVM	DFS	Tertile	All	0.338	0.804	.002	27	view →
OV	DFS	Quartile	IV	0.282	0.569	.004	24	view →
KICH	OS	Tertile	All	0.772	1.000	.012	23	view →
LUAD	OS	Median	II,III,IV	0.767	0.649	.005	22	view →
CESC	OS	Quartile	IV	0.797	0.237	.032	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ITGA6-AS1–MESO (DFS)

Open the MESO breakdown →