ITGA5

Across TCGA pan-cancer cohorts, ITGA5 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ITGA5 data layer compared with 27 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ITGA5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ITGA5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, OV, and UCEC are the cancer types where ITGA5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.156	0.759	.007	30	view →
OV	DFS	Median	II,III,IV	0.182	0.541	.011	30	view →
UCEC	DFS	Median	All	0.966	0.629	.012	18	view →
LIHC	OS	Median	All	0.156	0.777	.004	12	view →
COAD	OS	Median	IV	0.056	0.649	<.001	12	view →
ESCA	OS	Median	II,III,IV	0.136	0.687	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ITGA5–CESC (OS)

Open the CESC breakdown →