ITGA5

Across TCGA pan-cancer cohorts, ITGA5 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ITGA5 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ITGA5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGA5 expression acts as an unfavorable survival marker.

PDAC, CCRCC, and GBM are the cancer types where ITGA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.303	0.503	<.001	70	view →
CCRCC	DFS	Quartile	All	0.526	0.922	<.001	62	view →
GBM	DFS	Tertile	All	0.619	0.893	<.001	30	view →
LUAD	OS	Median	All	0.919	1.000	.001	25	view →
HNSC	OS	Quartile	All	0.577	0.812	.011	18	view →
LSCC	OS	Median	All	0.773	1.000	.011	5	view →
UCEC	DFS	Tertile	All	0.846	0.973	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ITGA5–PDAC (DFS)

Open the PDAC breakdown →