ITGA4

Across TCGA pan-cancer cohorts, ITGA4 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated ITGA4 data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ITGA4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ITGA4 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

READ, BLCA, and UCEC are the cancer types where ITGA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.111	0.919	<.001	27	view →
BLCA	OS	Median	II,III,IV	0.890	0.401	.002	24	view →
UCEC	DFS	Median	II,III,IV	0.945	0.427	.005	22	view →
BRCA	OS	Median	All	0.434	0.924	.012	18	view →
ACC	OS	Median	All	0.287	0.809	.001	12	view →
LUAD	DFS	Median	IV	0.045	0.717	<.001	12	view →
LUSC	OS	Median	III,IV	0.147	0.664	.028	12	view →
LIHC	DFS	Median	II,III,IV	0.140	0.434	.012	9	view →
PRAD	DFS	Median	All	0.817	0.934	.019	6	view →
LGG	OS	Median	All	0.332	0.830	.009	3	view →
SKCM	DFS	Median	III,IV	0.211	0.658	.027	3	view →
HNSC	DFS	Median	All	0.357	0.606	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

ITGA4–READ (OS)

Open the READ breakdown →