ITGA4

Across TCGA pan-cancer cohorts, ITGA4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ITGA4 data layer compared with 28 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ITGA4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ITGA4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where ITGA4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.616	0.459	.005	14	view →
CCRCC	DFS	Quartile	II,III,IV	0.915	0.376	.001	12	view →
LUAD	DFS	Tertile	III,IV	0.391	0.793	.047	4	view →
GBM	DFS	Tertile	All	0.259	0.479	.009	3	view →
HNSC	DFS	Median	IV	0.776	0.591	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ITGA4–PDAC (OS)

Open the PDAC breakdown →