ITGA3

Across TCGA cell cohorts, ITGA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,329 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ITGA3-associated GO terms across cancer lineages are Regulation of cell-substrate adhesion, Positive regulation of cell-substrate adhesion, and Regulation of cell-matrix adhesion. Each is linked with ITGA3 in more than 15 cancer types. Because this analysis shows association rather than direction, both ITGA3-to-partner and partner-to-ITGA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate adhesion grouped by ITGA3-low versus ITGA3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA3→partner) and Y-score (partner→ITGA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate adhesion →	+0.137	+4.066	<.001	<.001	3	16
BONE	Positive regulation of cell-substrate adhesion →	+0.160	+4.050	<.001	<.001	3	16
BONE	Regulation of cell-matrix adhesion →	+0.155	+4.485	<.001	<.001	3	16
BONE	Positive regulation of intracellular protein transport →	+0.087	+4.068	<.001	.002	3	16
LARGE_INTESTINE	Cellular response to environmental stimulus →	+0.055	+2.695	<.001	<.001	3	15
LIVER	Regulation of plasminogen activation →	+0.287	+3.559	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,329 associations by consensus.

Regulation of cell-substrate adhesion by ITGA3 expression — BONE

Explore this box plot interactively →