ITGA2B

Across TCGA patient cohorts, ITGA2B mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGA2B-associated genes across cancer lineages are ER-alpha_pS118, FoxM1, and MIG-6. Each is linked with ITGA2B in more than 3 cancer types. Because this analysis shows association rather than direction, both ITGA2B-to-partner and partner-to-ITGA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by ITGA2B-low versus ITGA2B-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA2B→partner) and Y-score (partner→ITGA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ER-alpha_pS118 →	+0.109	+3.000	.013	.036	3	3
STAD	FoxM1 →	+0.353	+2.838	.009	.033	3	3
COAD	MIG-6 →	+0.095	+3.644	.025	.001	3	3
UCEC	EGFR_pY1068 →	-0.163	-2.000	.046	.029	3	3
UCEC	TIGAR →	+0.102	+1.248	.040	.023	3	3
UCEC	ATM →	-0.469	-2.000	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ER-alpha_pS118 by ITGA2B expression — STAD

Explore this box plot interactively →