ITGA2B

Across TCGA cell cohorts, ITGA2B mutation is significantly associated with the RNA expression of many other genes, with 390 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGA2B-associated genes across cancer lineages are SULT2A1, VAPA, and PCCB. Each is linked with ITGA2B in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGA2B-to-partner and partner-to-ITGA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SULT2A1 grouped by ITGA2B-low versus ITGA2B-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA2B→partner) and Y-score (partner→ITGA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SULT2A1 →	+0.055	+4.321	<.001	.002	3	2
LARGE_INTESTINE	VAPA →	+0.573	+3.169	.001	.009	3	2
LARGE_INTESTINE	PCCB →	+0.729	+3.588	<.001	<.001	3	2
LARGE_INTESTINE	C6orf136 →	+0.581	+2.451	<.001	.009	3	2
LUNG_NSCLC_LUAD	MLC1 →	+0.339	+2.724	.001	.005	3	1
LUNG_NSCLC_LUAD	PAGE4 →	+0.269	+2.213	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 390 associations by consensus.

SULT2A1 by ITGA2B expression — CNS

Explore this box plot interactively →