ITGA2

Across TCGA cell cohorts, ITGA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,166 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ITGA2-associated GO terms across cancer lineages are Positive regulation of transmission of nerve impulse, Cellular response to environmental stimulus, and Cellular response to abiotic stimulus. Each is linked with ITGA2 in more than 18 cancer types. Because this analysis shows association rather than direction, both ITGA2-to-partner and partner-to-ITGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transmission of nerve impulse grouped by ITGA2-low versus ITGA2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA2→partner) and Y-score (partner→ITGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of transmission of nerve impulse →	+1.991	+3.331	<.001	<.001	3	19
BREAST	Cellular response to environmental stimulus →	+0.043	+1.706	<.001	.001	3	14
BREAST	Cellular response to abiotic stimulus →	+0.043	+1.706	<.001	.001	3	14
OVARY	Wound healing →	+0.100	+2.052	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Skin morphogenesis →	+0.235	+3.385	<.001	<.001	3	13
OESOPHAGUS	Positive regulation of chemotaxis →	+0.129	+1.899	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,166 associations by consensus.

Positive regulation of transmission of nerve impulse by ITGA2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →