ITGA11

Across TCGA pan-cancer cohorts, ITGA11 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ITGA11 data layer compared with 20 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ITGA11 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGA11 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, PDAC, and GBM are the cancer types where ITGA11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.436	0.879	<.001	34	view →
PDAC	DFS	Tertile	All	0.271	0.514	<.001	25	view →
GBM	OS	Tertile	All	0.289	0.751	.002	12	view →
LUAD	OS	Median	III,IV	0.821	0.276	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ITGA11–LSCC (DFS)

Open the LSCC breakdown →