ITGA11

Across TCGA patient cohorts, ITGA11 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ITGA11-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PDCD4, and GSK-3a-b_pS21_S9. Each is linked with ITGA11 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITGA11-to-partner and partner-to-ITGA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by ITGA11-low versus ITGA11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA11→partner) and Y-score (partner→ITGA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.432	-1.716	<.001	.003	3	3
COAD	PDCD4 →	-0.580	-3.321	<.001	.009	2	4
COAD	GSK-3a-b_pS21_S9 →	-0.300	-2.296	.045	.033	3	3
COAD	PCNA →	+0.394	+2.915	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.730	+2.915	<.001	<.001	3	2
COAD	EGFR_pY1068 →	-0.306	-2.321	.014	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

p38-MAPK_pT180_Y182 by ITGA11 expression — UCEC

Explore this box plot interactively →