ITGA11

Across TCGA cell cohorts, ITGA11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,567 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ITGA11-associated GO terms across cancer lineages are Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway, Establishment of protein localization to membrane, and Cellular response to environmental stimulus. Each is linked with ITGA11 in more than 10 cancer types. Because this analysis shows association rather than direction, both ITGA11-to-partner and partner-to-ITGA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway grouped by ITGA11-low versus ITGA11-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA11→partner) and Y-score (partner→ITGA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.091	+3.645	<.001	<.001	3	11
BONE	Establishment of protein localization to membrane →	+0.064	+4.012	.001	<.001	3	10
LIVER	Cellular response to environmental stimulus →	+0.069	+4.834	<.001	<.001	3	10
LIVER	Regulation of reactive oxygen species metabolic process →	+0.088	+2.916	.001	.005	3	10
LIVER	Cellular response to abiotic stimulus →	+0.069	+4.834	<.001	<.001	3	10
BONE	Regulation of cell-substrate junction organization →	+0.158	+3.358	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,567 associations by consensus.

Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway by ITGA11 expression — BONE

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