ITFG2

Across TCGA patient cohorts, ITFG2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITFG2-associated genes across cancer lineages are PRAS40_pT246, MEK1, and PDK1_pS241. Each is linked with ITFG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITFG2-to-partner and partner-to-ITFG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by ITFG2-low versus ITFG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITFG2→partner) and Y-score (partner→ITFG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.196	+3.335	.029	.005	3	2
UCEC	MEK1 →	+0.614	+3.321	.001	.010	3	1
UCEC	PDK1_pS241 →	+0.254	+2.833	.004	.034	3	1
UCEC	Rictor_pT1135 →	-0.131	-3.321	.015	.010	3	1
UCEC	Cyclin-B1 →	+0.652	+3.321	.026	.010	3	1
UCEC	eIF4E →	+0.249	+3.321	.024	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PRAS40_pT246 by ITFG2 expression — UCEC

Explore this box plot interactively →