ITFG2

Across TCGA cell cohorts, ITFG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,148 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ITFG2-associated GO terms across cancer lineages are Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, Meiotic chromosome condensation, and Leading strand elongation. Each is linked with ITFG2 in more than 14 cancer types. Because this analysis shows association rather than direction, both ITFG2-to-partner and partner-to-ITFG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by ITFG2-low versus ITFG2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITFG2→partner) and Y-score (partner→ITFG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.162	+1.038	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Meiotic chromosome condensation →	+0.194	+0.868	<.001	<.001	3	14
PANCREAS	Leading strand elongation →	+0.166	+0.736	<.001	.002	2	15
BONE	DNA recombination →	+0.105	+1.412	.003	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Mitotic cell cycle checkpoint signaling →	+0.090	+0.877	.001	<.001	3	14
SOFT_TISSUE	Regulation of DNA repair →	+0.063	+0.699	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,148 associations by consensus.

Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I by ITFG2 expression — SOFT_TISSUE

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