ITFG2

Across TCGA cell cohorts, ITFG2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITFG2-associated genes across cancer lineages are GJD2, BPIFB6, and HTR1E. Each is linked with ITFG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITFG2-to-partner and partner-to-ITFG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD2 grouped by ITFG2-low versus ITFG2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITFG2→partner) and Y-score (partner→ITFG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJD2 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	HTR1E →	+0.070	+3.345	<.001	.007	3	1
LARGE_INTESTINE	UTF1 →	+0.018	+3.632	<.001	.003	3	1
LARGE_INTESTINE	TMEM233 →	+0.293	+3.196	.001	.007	3	1
LARGE_INTESTINE	FAM218A →	+0.377	+3.658	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GJD2 by ITFG2 expression — LARGE_INTESTINE

Explore this box plot interactively →