ITFG1

Across TCGA pan-cancer cohorts, ITFG1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ITFG1 data layer compared with 18 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ITFG1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ITFG1 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

LSCC, GBM, and PDAC are the cancer types where ITFG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.395	1.000	<.001	80	view →
GBM	DFS	Tertile	All	0.949	0.630	<.001	14	view →
PDAC	OS	Tertile	II,III,IV	0.614	0.423	.024	8	view →
CCRCC	OS	Quartile	All	0.698	1.000	.031	1	view →
LUAD	DFS	Tertile	All	0.675	0.849	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ITFG1–LSCC (OS)

Open the LSCC breakdown →