ITFG1

Across TCGA pan-cancer cohorts, ITFG1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ITFG1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ITFG1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ITFG1 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

LUAD, HNSC, and COAD are the cancer types where ITFG1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITFG1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+0.478	<.001	8	view →
HNSC	Male	All	−0.216	<.001	6	view →
COAD	Male	II,III,IV	−0.220	.012	5	view →
LSCC	Male	All	−0.131	<.001	4	view →
CCRCC	Female	All	+0.225	.003	2	view →
PDAC	Male	IV	+0.445	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ITFG1–LUAD

Open the LUAD breakdown →