ITFG1

Across TCGA patient cohorts, ITFG1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITFG1-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and EGFR. Each is linked with ITFG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITFG1-to-partner and partner-to-ITFG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ITFG1-low versus ITFG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITFG1→partner) and Y-score (partner→ITFG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.096	-2.973	.025	.035	3	1
UCEC	EGFR_pY1068 →	-0.295	-2.906	.005	.001	3	1
UCEC	EGFR →	-0.170	-1.700	.012	.044	3	1
UCEC	INPP4B →	-0.330	-3.169	.016	.018	3	1
UCEC	JNK2 →	+0.205	+2.222	.015	.011	3	1
UCEC	Notch1 →	+0.175	+1.750	.003	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

14-3-3_beta by ITFG1 expression — UCEC

Explore this box plot interactively →