ITFG1-AS1

Across TCGA pan-cancer cohorts, ITFG1-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ITFG1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ITFG1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITFG1-AS1 is over-expressed in tumor, although a few such as THCA and PAAD show the opposite, repressed pattern.

HNSC, THCA, and KIRC are the cancer types where ITFG1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITFG1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.270	<.001	10	view →
THCA	All	II,III,IV	−0.386	<.001	8	view →
KIRC	Male	All	+0.246	<.001	7	view →
LIHC	All	All	+0.157	<.001	7	view →
KICH	Female	III,IV	+1.206	<.001	5	view →
CHOL	Female	All	+0.826	<.001	5	view →
BLCA	All	III,IV	+0.272	.003	4	view →
BRCA	Female	All	+0.252	<.001	4	view →
LUAD	All	All	+0.293	.008	3	view →
COAD	All	II,III,IV	+0.214	.018	3	view →
UCEC	All	II,III,IV	+0.387	.047	2	view →
STAD	All	II,III,IV	+0.351	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ITFG1-AS1–HNSC

Open the HNSC breakdown →