ITCH-AS1

Across TCGA pan-cancer cohorts, ITCH-AS1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated ITCH-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ITCH-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITCH-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and OV show a favorable association.

UVM, THCA, and THYM are the cancer types where ITCH-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.032	0.727	<.001	54	view →
THCA	OS	Tertile	II,III,IV	0.648	0.936	.002	33	view →
THYM	OS	Tertile	All	0.926	0.982	.008	30	view →
PAAD	DFS	Tertile	II,III,IV	0.293	0.481	.008	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
KIRC	OS	Quartile	All	0.758	0.818	.028	12	view →
ESCA	OS	Tertile	III,IV	0.635	0.311	.008	11	view →
COAD	OS	Tertile	III,IV	0.606	0.814	.027	9	view →
STAD	DFS	Median	II,III,IV	0.459	0.599	.009	6	view →
SKCM	DFS	Tertile	All	0.635	0.749	.029	3	view →
OV	DFS	Quartile	All	0.235	0.147	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

ITCH-AS1–UVM (DFS)

Open the UVM breakdown →