ISYNA1

Across TCGA pan-cancer cohorts, ISYNA1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ISYNA1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ISYNA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ISYNA1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where ISYNA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.384	1.000	.006	44	view →
PDAC	OS	Quartile	II,III,IV	0.772	0.317	.001	31	view →
CCRCC	DFS	Tertile	III,IV	0.854	0.395	.004	17	view →
GBM	DFS	Tertile	All	0.481	0.255	.009	4	view →
LSCC	OS	Quartile	II,III,IV	0.899	0.666	.018	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ISYNA1–UCEC (DFS)

Open the UCEC breakdown →