ISYNA1

Across TCGA patient cohorts, ISYNA1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISYNA1-associated genes across cancer lineages are Akt, Annexin-1, and EGFR_pY1068. Each is linked with ISYNA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISYNA1-to-partner and partner-to-ISYNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt grouped by ISYNA1-low versus ISYNA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISYNA1→partner) and Y-score (partner→ISYNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Akt →	-1.103	-3.161	<.001	.019	3	2
UCEC	Annexin-1 →	+0.888	+3.019	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.243	-2.700	.009	.006	3	2
UCEC	MSH6 →	-0.356	-3.169	.003	.018	3	2
UCEC	VHL →	-0.887	-1.700	<.001	.040	3	2
UCEC	ATM →	-0.658	-3.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Akt by ISYNA1 expression — COAD

Explore this box plot interactively →