ISYNA1

Across TCGA cell cohorts, ISYNA1 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISYNA1-associated genes across cancer lineages are MSH4, TRIM60, and OR2D3. Each is linked with ISYNA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISYNA1-to-partner and partner-to-ISYNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH4 grouped by ISYNA1-low versus ISYNA1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISYNA1→partner) and Y-score (partner→ISYNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MSH4 →	+0.143	+3.318	<.001	.007	3	2
SOFT_TISSUE	TRIM60 →	+0.375	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR2D3 →	+0.028	+4.930	<.001	.008	3	1
SOFT_TISSUE	TAS2R38 →	+0.035	+5.369	<.001	.004	3	1
BLOOD_Leukemia	SLC32A1 →	+0.406	+2.638	.003	.009	3	1
BLOOD_Leukemia	PHOX2B →	+0.018	+3.687	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

MSH4 by ISYNA1 expression — BLOOD_Leukemia

Explore this box plot interactively →