ISYNA1

Across TCGA cell cohorts, ISYNA1 mutation is significantly associated with the mutation status of many other genes, with 5,012 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISYNA1-associated genes across cancer lineages are SH2B3, TSGA10, and UBAP2. Each is linked with ISYNA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ISYNA1-to-partner and partner-to-ISYNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH2B3 grouped by ISYNA1-low versus ISYNA1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISYNA1→partner) and Y-score (partner→ISYNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SH2B3 →	+5.415	+5.415	.004	.004	1	4
OVARY	TSGA10 →	+4.415	+4.977	.007	.007	1	4
BLOOD_Lymphoma	UBAP2 →	+6.014	+6.014	.001	.001	1	4
BLOOD_Lymphoma	CILP2 →	+5.014	+5.584	.003	.003	1	4
OVARY	ADCY6 →	+4.415	+4.977	.007	.007	1	4
BLOOD_Lymphoma	ZNF48 →	+6.014	+6.014	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,012 associations by consensus.

SH2B3 by ISYNA1 expression — OVARY

Explore this box plot interactively →