ISY1

Across TCGA pan-cancer cohorts, ISY1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ISY1 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher ISY1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ISY1 expression acts as an unfavorable survival marker.

LUSC, SKCM, and DLBC are the cancer types where ISY1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.181	0.776	.004	24	view →
SKCM	OS	Median	All	0.233	0.787	.003	15	view →
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ISY1–LUSC (OS)

Open the LUSC breakdown →