ISY1

Across TCGA patient cohorts, ISY1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,771 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ISY1-associated proteins across cancer lineages are MCM3, MCM4, and MCM6. Each is linked with ISY1 in more than 7 cancer types. Because this analysis shows association rather than direction, both ISY1-to-partner and partner-to-ISY1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISY1 versus MCM3 in LUAD, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ISY1→partner) and Y-score (partner→ISY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM3 →	+0.707	+0.394	<.001	<.001	3	8
LUAD	MCM4 →	+0.755	+0.400	<.001	<.001	3	8
LUAD	MCM6 →	+0.766	+0.377	<.001	<.001	3	8
LSCC	ZNF148 →	+0.323	+0.579	<.001	<.001	3	8
HNSC	RFC2 →	+0.445	+0.533	<.001	.004	3	7
HNSC	RFC5 →	+0.444	+0.674	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,771 associations by consensus.

ISY1 vs MCM3 — LUAD

Explore this scatter interactively →