ISY1

Across TCGA cell cohorts, ISY1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,394 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible ISY1-associated GO terms across cancer lineages are mRNA 3'-splice site recognition, Double-strand break repair via nonhomologous end joining, and DNA-templated DNA replication. Each is linked with ISY1 in more than 19 cancer types. Because this analysis shows association rather than direction, both ISY1-to-partner and partner-to-ISY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA 3'-splice site recognition grouped by ISY1-low versus ISY1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISY1→partner) and Y-score (partner→ISY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	mRNA 3'-splice site recognition →	+0.182	+1.027	<.001	<.001	3	20
OESOPHAGUS	Double-strand break repair via nonhomologous end joining →	+0.068	+0.776	.008	.001	3	17
BLOOD_Lymphoma	DNA-templated DNA replication →	+0.098	+0.979	<.001	<.001	3	16
BREAST	Positive regulation of cell cycle process →	+0.113	+1.073	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Nuclear division →	+0.069	+0.745	.004	<.001	3	15
LUNG_NSCLC_LUSC	Protein localization to chromosome →	+0.112	+1.012	.002	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,394 associations by consensus.

mRNA 3'-splice site recognition by ISY1 expression — KIDNEY

Explore this box plot interactively →