IST1

Across TCGA pan-cancer cohorts, IST1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IST1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IST1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IST1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, LUAD, and COAD are the cancer types where IST1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.858	0.185	.006	28	view →
LUAD	OS	Tertile	II,III,IV	0.756	1.000	.022	13	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
PDAC	DFS	Median	All	0.368	0.203	.006	5	view →
GBM	DFS	Median	All	0.649	0.783	.005	5	view →
LSCC	DFS	Quartile	II,III,IV	0.587	0.922	.032	3	view →
UCEC	DFS	Median	II,III,IV	0.826	1.000	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IST1–HNSC (DFS)

Open the HNSC breakdown →