IST1

Across TCGA patient cohorts, IST1 mutation is significantly associated with the RNA expression of many other genes, with 121 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IST1-associated genes across cancer lineages are ATP5F1EP1, RNA5SP411, and MOCS2. Each is linked with IST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IST1-to-partner and partner-to-IST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5F1EP1 grouped by IST1-low versus IST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IST1→partner) and Y-score (partner→IST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP5F1EP1 →	+0.380	+2.670	<.001	.009	3	2
UCEC	RNA5SP411 →	+1.581	+2.978	<.001	.001	3	2
UCEC	MOCS2 →	+0.581	+3.218	.004	.009	3	1
UCEC	DTYMK →	+0.695	+3.234	.003	.009	3	1
UCEC	PDP2 →	+0.836	+3.234	<.001	.009	3	1
UCEC	EIF1AD →	+0.481	+3.223	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 121 associations by consensus.

ATP5F1EP1 by IST1 expression — UCEC

Explore this box plot interactively →