IST1

Across TCGA patient cohorts, IST1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IST1-associated genes across cancer lineages are FoxM1, FASN, and PEA-15_pS116. Each is linked with IST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IST1-to-partner and partner-to-IST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by IST1-low versus IST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IST1→partner) and Y-score (partner→IST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.306	+2.817	.041	.036	3	1
UCEC	FASN →	+0.735	+3.000	.001	.037	1	1
UCEC	PEA-15_pS116 →	-0.498	-3.000	.014	.037	1	1
UCEC	Annexin_VII →	-0.164	-3.000	.041	.037	1	1
UCEC	C-Raf →	+0.304	+3.000	<.001	.037	1	1
UCEC	Cyclin-B1 →	+0.693	+3.000	.032	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FoxM1 by IST1 expression — UCEC

Explore this box plot interactively →