IST1

Across TCGA cell cohorts, IST1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,902 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IST1-associated GO terms across cancer lineages are Regulation of organelle assembly, Viral transcription, and Basolateral protein secretion. Each is linked with IST1 in more than 15 cancer types. Because this analysis shows association rather than direction, both IST1-to-partner and partner-to-IST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of organelle assembly grouped by IST1-low versus IST1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IST1→partner) and Y-score (partner→IST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of organelle assembly →	+0.041	+0.647	<.001	<.001	3	16
URINARY_TRACT	Viral transcription →	+0.125	+0.803	<.001	<.001	3	16
URINARY_TRACT	Basolateral protein secretion →	+0.170	+0.681	.002	.001	3	14
STOMACH	Macroautophagy →	+0.084	+0.825	<.001	<.001	3	14
STOMACH	Protein polyubiquitination →	+0.056	+0.669	.001	.009	3	14
LARGE_INTESTINE	Golgi vesicle transport →	+0.066	+0.730	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,902 associations by consensus.

Regulation of organelle assembly by IST1 expression — URINARY_TRACT

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