IST1

Across TCGA cell cohorts, IST1 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IST1-associated genes across cancer lineages are SH3GL2, BVES, and SERAC1. Each is linked with IST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IST1-to-partner and partner-to-IST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by IST1-low versus IST1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IST1→partner) and Y-score (partner→IST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.295	+3.252	<.001	.009	3	1
LARGE_INTESTINE	BVES →	+0.387	+3.355	.004	.007	3	1
LARGE_INTESTINE	SERAC1 →	+1.013	+3.067	<.001	.009	3	1
LARGE_INTESTINE	NUDT10 →	+0.344	+3.748	<.001	.001	3	1
LARGE_INTESTINE	CILP →	+0.157	+3.706	<.001	.002	3	1
LARGE_INTESTINE	INTS12 →	+0.550	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

SH3GL2 by IST1 expression — LARGE_INTESTINE

Explore this box plot interactively →