IST1

Across TCGA cell cohorts, IST1 mutation is significantly associated with the mutation status of many other genes, with 2,388 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IST1-associated genes across cancer lineages are CBLN1, SH3GL1, and STEAP3. Each is linked with IST1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IST1-to-partner and partner-to-IST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBLN1 grouped by IST1-low versus IST1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IST1→partner) and Y-score (partner→IST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CBLN1 →	+6.014	+6.014	.001	.001	1	3
BLOOD_Lymphoma	SH3GL1 →	+5.014	+5.584	.003	.003	1	3
SKIN	STEAP3 →	+4.824	+5.392	.004	.004	1	3
SKIN	ATP2A1 →	+4.239	+5.053	.007	.007	1	2
SKIN	LRP8 →	+4.239	+5.053	.007	.007	1	2
SKIN	GPR35 →	+5.824	+5.824	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,388 associations by consensus.

CBLN1 by IST1 expression — BLOOD_Lymphoma

Explore this box plot interactively →