ISOC2

Across TCGA patient cohorts, ISOC2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,933 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ISOC2-associated genes across cancer lineages are PFN1, NCAPG, and TTK. Each is linked with ISOC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ISOC2-to-partner and partner-to-ISOC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISOC2 versus PFN1 in COAD, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISOC2→partner) and Y-score (partner→ISOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PFN1 →	-0.461	-0.291	<.001	.005	3	5
GBM	NCAPG →	-1.050	-0.273	<.001	.002	3	5
GBM	TTK →	-1.179	-0.315	<.001	<.001	3	5
GBM	ZWINT →	-1.103	-0.381	<.001	<.001	3	5
COAD	COPS3 →	-0.580	-0.463	<.001	<.001	3	5
LSCC	WRAP53 →	-0.457	-0.268	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,933 associations by consensus.

ISOC2 vs PFN1 — COAD

Explore this scatter interactively →