ISOC2

Across TCGA patient cohorts, ISOC2 mutation is significantly associated with the RNA expression of many other genes, with 111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISOC2-associated genes across cancer lineages are RNA5SP509, RNA5SP407, and TRAPPC2P3. Each is linked with ISOC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISOC2-to-partner and partner-to-ISOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP509 grouped by ISOC2-low versus ISOC2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISOC2→partner) and Y-score (partner→ISOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP509 →	+0.373	+7.924	<.001	.008	3	2
LUSC	RNA5SP407 →	+0.397	+7.924	<.001	.008	3	1
LUSC	TRAPPC2P3 →	+0.134	+7.924	<.001	.008	3	1
LUSC	MTND6P17 →	+0.103	+7.924	<.001	.008	3	1
LUSC	RNU6-1129P →	+0.410	+7.924	<.001	.008	3	1
UCEC	MIR3688-1 →	+0.340	+4.245	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 111 associations by consensus.

RNA5SP509 by ISOC2 expression — LUSC

Explore this box plot interactively →