ISOC2

Across TCGA cell cohorts, ISOC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,177 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ISOC2-associated GO terms across cancer lineages are Aerobic respiration, Ribonucleoside triphosphate biosynthetic process, and ATP metabolic process. Each is linked with ISOC2 in more than 9 cancer types. Because this analysis shows association rather than direction, both ISOC2-to-partner and partner-to-ISOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aerobic respiration grouped by ISOC2-low versus ISOC2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISOC2→partner) and Y-score (partner→ISOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Aerobic respiration →	+0.103	+0.841	.001	.002	3	10
UPPER_AERODIGESTIVE_TRACT	Ribonucleoside triphosphate biosynthetic process →	+0.084	+0.833	<.001	<.001	3	10
BONE	ATP metabolic process →	+0.087	+0.604	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Fatty acid catabolic process →	+0.082	+1.040	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Proton motive force-driven ATP synthesis →	+0.109	+1.010	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	ATP biosynthetic process →	+0.093	+1.024	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,177 associations by consensus.

Aerobic respiration by ISOC2 expression — LIVER

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