ISOC1

Across TCGA pan-cancer cohorts, ISOC1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ISOC1 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ISOC1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ISOC1 expression acts as an unfavorable survival marker.

BLCA, SKCM, and SCLC are the cancer types where ISOC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.141	0.710	<.001	39	view →
SKCM	OS	Median	All	0.230	0.781	.004	15	view →
SCLC	OS	Median	All	0.082	0.708	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ISOC1–BLCA (OS)

Open the BLCA breakdown →