ISOC1

Across TCGA patient cohorts, ISOC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,044 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ISOC1-associated proteins across cancer lineages are NUDT12, KDM3B, and HSPA4. Each is linked with ISOC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ISOC1-to-partner and partner-to-ISOC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISOC1 versus NUDT12 in BRCA, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ISOC1→partner) and Y-score (partner→ISOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUDT12 →	+0.560	+0.744	<.001	<.001	3	6
LSCC	KDM3B →	+0.254	+0.498	<.001	<.001	3	6
OV	HSPA4 →	+0.299	+0.599	<.001	<.001	3	6
BRCA	C5orf24 →	+0.406	+1.174	<.001	<.001	3	5
LSCC	GEMIN5 →	+0.243	+0.404	<.001	<.001	3	5
GBM	MCM6 →	+0.627	+0.298	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,044 associations by consensus.

ISOC1 vs NUDT12 — BRCA

Explore this scatter interactively →