ISOC1

Across TCGA patient cohorts, ISOC1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,058 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ISOC1-associated genes across cancer lineages are MMP14, MDFI, and MFAP2. Each is linked with ISOC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both ISOC1-to-partner and partner-to-ISOC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISOC1 versus MMP14 in OV, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISOC1→partner) and Y-score (partner→ISOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MMP14 →	-0.961	-0.310	<.001	<.001	3	7
GBM	MDFI →	-1.074	-0.320	.001	<.001	3	6
OV	MFAP2 →	-0.963	-0.263	.004	.004	3	6
OV	P3H1 →	-0.787	-0.407	.006	.001	3	6
LUAD	PLAU →	-1.134	-0.235	<.001	.001	3	6
LUAD	LOXL2 →	-1.113	-0.274	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,058 associations by consensus.

ISOC1 vs MMP14 — OV

Explore this scatter interactively →