ISOC1

Across TCGA patient cohorts, ISOC1 mutation is significantly associated with the RNA expression of many other genes, with 1,369 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISOC1-associated genes across cancer lineages are RNA5SP414, MIR194-1, and MIR193BHG. Each is linked with ISOC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISOC1-to-partner and partner-to-ISOC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by ISOC1-low versus ISOC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISOC1→partner) and Y-score (partner→ISOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.691	+2.407	<.001	.006	3	2
UCEC	MIR194-1 →	+0.676	+2.349	<.001	.004	3	2
UCEC	MIR193BHG →	+0.765	+3.225	<.001	.009	3	1
UCEC	SAMD11P1 →	+0.208	+2.504	.009	.002	3	1
UCEC	RN7SL381P →	+0.587	+3.721	.002	<.001	3	1
UCEC	MIR4672 →	+0.665	+3.041	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,369 associations by consensus.

RNA5SP414 by ISOC1 expression — UCEC

Explore this box plot interactively →