ISOC1

Across TCGA patient cohorts, ISOC1 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISOC1-associated genes across cancer lineages are Erythrocytes, Osteoblast, and lymphatic Endothelial cells. Each is linked with ISOC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISOC1-to-partner and partner-to-ISOC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Erythrocytes grouped by ISOC1-low versus ISOC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISOC1→partner) and Y-score (partner→ISOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Erythrocytes →	+0.038	+2.180	<.001	.034	3	2
LUAD	Osteoblast →	+0.033	+2.909	.004	.019	3	1
UCEC	lymphatic Endothelial cells →	-0.029	-3.646	.008	.001	2	1
UCEC	Endothelial cells →	-0.048	-3.657	.007	.001	1	1
UCEC	mv Endothelial cells →	-0.030	-3.689	.005	.001	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Erythrocytes by ISOC1 expression — UCEC

Explore this box plot interactively →