ISM2

Across TCGA patient cohorts, ISM2 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,532 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ISM2-associated proteins across cancer lineages are CASP1, PSMB10, and PSMB10_S230. Each is linked with ISM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ISM2-to-partner and partner-to-ISM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISM2 versus CASP1 in COAD, with a Pearson correlation of -0.26.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ISM2→partner) and Y-score (partner→ISM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CASP1 →	-0.507	-0.683	<.001	.002	3	4
COAD	PSMB10 →	-0.420	-0.743	<.001	<.001	3	3
LSCC	PSMB10_S230 →	-0.696	-0.740	.001	<.001	3	3
LSCC	GCLC →	+0.791	+0.434	<.001	.003	3	3
LSCC	GMPPA →	-0.393	-0.720	<.001	.001	3	3
LSCC	SCLY →	-0.396	-0.752	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,532 associations by consensus.

ISM2 vs CASP1 — COAD

Explore this scatter interactively →