ISM2

Across TCGA patient cohorts, ISM2 mutation is significantly associated with the RNA expression of many other genes, with 1,325 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISM2-associated genes across cancer lineages are MIR4441, RNA5SP27, and MIR507. Each is linked with ISM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ISM2-to-partner and partner-to-ISM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4441 grouped by ISM2-low versus ISM2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISM2→partner) and Y-score (partner→ISM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR4441 →	+0.317	+4.424	<.001	.008	3	3
PRAD	RNA5SP27 →	+0.317	+7.939	<.001	.008	3	2
PRAD	MIR507 →	+0.363	+7.939	<.001	.008	3	2
UCEC	FAM177A1 →	+0.368	+2.823	.002	.001	3	2
UCEC	CENPU →	+0.633	+2.949	.004	<.001	3	2
UCEC	GPATCH11 →	+0.423	+2.180	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,325 associations by consensus.

MIR4441 by ISM2 expression — HNSC

Explore this box plot interactively →