ISM2

Across TCGA patient cohorts, ISM2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISM2-associated genes across cancer lineages are eIF4G, Acetyl-a-Tubulin-Lys40, and JNK2. Each is linked with ISM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISM2-to-partner and partner-to-ISM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by ISM2-low versus ISM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISM2→partner) and Y-score (partner→ISM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.297	+2.999	.024	.035	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.484	+2.222	.025	.011	3	1
UCEC	JNK2 →	+0.196	+2.834	.020	.034	3	1
UCEC	Notch1 →	+0.193	+2.222	.001	.011	3	1
UCEC	p62 Lck ligand →	+0.515	+2.906	<.001	.001	3	1
UCEC	p90 RSK →	+0.205	+2.469	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

eIF4G by ISM2 expression — UCEC

Explore this box plot interactively →