ISM2

Across TCGA cell cohorts, ISM2 mutation is significantly associated with the RNA expression of many other genes, with 101 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISM2-associated genes across cancer lineages are GYPB, GABRA6, and TAAR8. Each is linked with ISM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISM2-to-partner and partner-to-ISM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GYPB grouped by ISM2-low versus ISM2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISM2→partner) and Y-score (partner→ISM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GYPB →	+0.080	+3.544	.001	.009	3	2
LUNG_NSCLC_LUAD	GABRA6 →	+0.066	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	XAGE3 →	+0.126	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	GAGE12F →	+1.131	+3.977	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

GYPB by ISM2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →